Amendment No. 4 To Collaboration Agreement

AMENDMENT NO. 4 TO COLLABORATION AGREEMENT
BAYER AG - SYMYX TECHNOLOGIES


This Amendment No. 4 to Collaboration Agreement (the "Fourth Amendment"), effective as of September 15, 1999, is entered into by and between Symyx Technologies ("Symyx"), a Delaware corporation having a principal place of business at 3100 Central Expressway, Santa Clara, California 95051 ("Symyx"), and Bayer AG, a German corporation, having a principal place of business at D-51368 Leverkusen, Germany, and amends that certain Collaboration Agreement entered into by and between Symyx and Bayer effective as of March 1, 1998, as previously amended by Amendment No 1 to Collaboration Agreement effective as of May 1, 1998, Amendment No. 2 to Collaboration Agreement effective as of November 1, 1998 and Amendment No. 3 to Collaboration Agreement effective as of January 1, 1999 (the "Collaboration Agreement").


WHEREAS, Symyx and Bayer desire to amend the Collaboration Agreement to provide for continuation of the Research Program in [******];


NOW THEREFORE, the parties hereby agree as follows:


1. All capitalized terms not defined in this Fourth Amendment shall have
the meanings given to them in the Collaboration Agreement.


2. Section 2.2.1(b) is amended to read in its entirety as follows:


(b) [******]


3. Section 2.2 is amended by addition of the following new Section 2.2.6:


2.2.6 [******]


4. Section 2.4 is amended to r ...