Employment Agreement W/ Alan Crane

MYCO PHARMACEUTICALS INC. LETTERHEAD]


CONFIDENTIAL


June 21, 1995


Mr. Alan Crane 217 Varick Road Waban, MA 02168


Dear Alan:


We are pleased with the prospect of your joining Myco Pharmaceuticals as an employee and to offer you the position of Executive Director-Business Development. We believe you will find your position challenging and professionally rewarding. Terms of the offer are as follows:


Responsibilities: You will be responsible for analyzing, planning and as noted below implementing business development at Myco. Your responsibilities will involve both strategic and operational tasks including the following: seek and work to ensure the success of present and future strategic alliances; enhance Myco's development as a business and research, analyze and recommend pathways to optimize Myco's value and revenue stream; identify, analyze, prioritize, recommend and, as appropriate, negotiate product and technology opportunities and research agreements; prepare and update Myco's business strategy and business plan; meet with investment bankers, stock analysts, venture capitalists, and senior business development executives from other organizations to discuss strategic alliances, business deals, licensing, fund raising and valuation issues so as to optimize Myco's development as an effective and profitable business; work with high diligence and commitment to achieve the goals of the Company and ensure effective communication and cooperation with your colleagues in the Company; ...