First Amendment To Issuing And Paying Agency Agreement

Exhibit 10.01

FIRST AMENDMENT TO ISSUING AND PAYING AGENCY AGREEMENT

The Bank of New York, as Issuing and Paying Agent

101 Barclay Street, Floor 8 West

New York, New York 10286

Attn: Corporate Trust Administration

Re: Cardinal Health, Inc.

Ladies and Gentlemen: This letter (the " First Amendment" ) sets forth the understanding between you and Cardinal Health, Inc. (the " Company" ), whereby we have agreed to amend that certain Issuing and Paying Agency Agreement by and between you and the Company dated August 9, 2006 (the " Issuing and Paying Agency Agreement" ) in order to increase to $1,500,000,000 the limit as to the aggregate principal amount of commercial paper notes which may be outstanding at any given time pursuant to such agreement.

1. Defined Terms . Unless the context as used herein requires otherwise, capitalized terms used but not defined in this First Amendment shall have the meaning given to them in the Issuing and Paying Agency Agreement. 2. Amendment . Paragraph 4(a)(i) of the Issuing and Paying Agency Agreement is hereby deleted in its en ...