Vice President, Business Development Employment Agreement

EXHIBIT 10.15


[NITROMED LETTERHEAD]


Michael D. Loberg, Ph.D.
CHIEF EXECUTIVE OFFICER
mloberg@nitromed.com


April 22, 1999


Mr. Joseph Grimm 174 Marlborough Street Boston, Massachusetts 02116


Dear Joe:


The Management and Board of NitroMed have enjoyed meeting you and are enthusiastic to have you join our senior management team. As such, we would like to formally offer you the position of Senior Vice President, Business Development and Chief Financial Officer, reporting to me as Chief Executive Officer.


The terms of the offer are described below:


Start Date: April 19, 1999


Base Salary: $180,000 to be reviewed annually and adjusted by
the Board's Compensation Committee to reflect
performance.


Performance Bonus: Beginning in 1999 an annual bonus based upon
performance and the achievement of milestones
mutually agreed upon by you, me and the Board of
Directors in an amount up to 22% of base salary
in accordance with the NitroMed Incentive
Compensation Plan (copy attached).


Stock: Options granted under the Company's Stock Option
Plan of 100,000 shares of the Company's Common
Stock. These options will vest in equal
installments over a four year period, beginning
on the first anniversary of your employment in
accordance with the NitroMed Stock Option Plan
...