Vice President, Business Development Employment Agreement

October 21, 1999 Helen S. Kim 6125 Ruthland Road Oakland, CA 94611 Dear Helen:


On behalf of Onyx Pharmaceuticals, it is a great pleasure to offer you the position of Vice President, Business Development, reporting to me. In making this offer, we are expressing our enthusiastic support for the skills and commitment you bring to our exciting team. We are pleased to offer you the following:


SALARY: Your salary will be $225,000 per year. In addition, you will be paid a $25,000 sign-on bonus and be eligible for the management bonus plan. If you separate from the company voluntarily within six months from your date of hire, we expect that you will repay this sign-on bonus.


STOCK: Subject to approval by our Board of Directors, you will be granted 40,000 options to purchase Onyx shares at the market price on your start date. The options will be issued pursuant to the Company's standard Option Agreement. These options will be exercisable in installments based upon your continued employment as follows: 25% after the first twelve months, 1/48th per month thereafter, for a total of a four-year vesting period.


BENEFITS: You will be eligible to participate in the Company's group insurance and benefits plans including:


1. A choice of medical coverage provided by either Aetna US Healthcare or
Kaiser Permanente and dental coverage provided by Delta Dental;


2. Life insurance equal to two times your annual salary;

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