Senior Vice President Business Development Employment Agreement

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Exhibit 10.25


Advanced Medicine

June 30, 2000
Revised offer

David Brinkley
62 Giggleswick Way
Edison, NJ 08820

Dear David:

Advanced Medicine, Inc. ("AMI" or the "Company") is pleased to offer you the exempt position of Senior Vice President Business Development, reporting to Marty Glick. Your salary on an annualized basis will be $230,000. You will also be eligible to participate in Advanced Medicine's Management Incentive Bonus up to 30% of your base salary. In addition, you will be paid an employment bonus of $50,000, grossed up and payable in your first paycheck. If you choose to leave AMI within the first year of your employment this bonus will be fully repayable to Advanced Medicine. Please see page three for relocation and additional details of your offer of employment.

Pursuant to your Consulting Agreement dated June 17, 2000, you have been granted an option to purchase 200,000 shares of Common Stock of the Company. After your employment start date, you will continue to vest in such option shares pursuant to the terms of the Stock Option Agreement and the Company's Stock Option Plan. Your employment start date will be September 1st, 2000.

AMI provides a comprehensive company-paid benefits package that begins on your first day of employment. Your benefits are provided by AMI at no cost to you. Dependent coverage is also provided at minimal cost. Included are medical, vision and dental coverage, life insurance, long-term disability insurance and a flexible spending plan. Additionally, we offer a 401(k) plan, which provides you with the opportunity for pre-tax long-term savings by deferring 1-15% of your annual salary. You will also receive 3 weeks of paid vacation ...