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Adoption Agreement

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The CORPORATE plan for Retirement SM
EXECUTIVE PLAN





Adoption Agreement





IMPORTANT NOTE



This document has not been approved by the Department of Labor, the Internal Revenue Service or any other governmental entity. An Adopting Employer must determine whether the plan is subject to the Federal securities laws and the securities laws of the various states. An Adopting Employer may not rely on this document to ensure any particular tax consequences or to ensure that the Plan is "unfunded and maintained primarily for the purpose of providing deferred compensation to a select group of management or highly compensated employees" under the Employee Retirement Income Security Act with respect to the Employer92s particular situation. Fidelity Management Trust Company, its affiliates and employees cannot provide you with legal advice in connection with the execution of this document. This document should be reviewed by the Employer92s attorney prior to execution.








ADOPTION AGREEMENT



ARTICLE 1



1.01 PLAN INFORMATION

(a) Name of Plan:

This is the Amylin Pharmaceuticals, Inc. 2001 Non-Qualified Deferred Compensation Plan (the "Plan").

(b) Name of Plan Administrator, if not the Employer:


Address:


Phone Number:

The Plan Administrator is the agent for service of legal process for the Plan.

(c) Plan Year End is December 31.

(d) Plan Status (check one):

(1) o Effective Date of new Plan:

(2) fd Amendment Effective Date: 1/1/2005

The original effective date of the Plan: 4/1/2000

1.02 EMPLOYER

(a) The Employer is : Amylin Pharmaceuticals, Inc.

Address: 9360 Towne Center Drive
Suite 110
San Diego, CA 92121
Contact92s Name: Ms. Sue Baccino
Telephone Number: (858) 642-7098

(1) Employer92s Tax Identification Number: 33-0266089

(2) Business form of Employer (check one):

(A) fd Corporation (Other than a Subchapter S corporation)

(B) a8 Other (e.g., Subchapter S corporation, partnership, sole proprietor)

(3) Employer92s fiscal year end: 12/31





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(b) The term "Employer" includes the following Related Employer(s)
(as defined in Section 2.01(a)(24)):

1.03 COVERAGE

(a) The following Employees are eligible to participate in the Plan:

(1) o Only those Employees listed in Attachment A will be eligible to participate in the Plan.

(2) fd Only those Employees in the eligible class described below will be eligible to participate in the Plan:
(a) Non-employee board Members; (b) Employees internally designated as " Directors" or higher and whose compensation exceeds the amount defined in section 414(q) of the Internal Revenue Code by at least $10,000.




(3) a8 Only those Employees described in the Board of Directors Resolutions attached hereto and hereby made a part hereof will be eligible to participate in the Plan.

(b) The Entry Date(s) shall be (check one):
(1) a8 each January 1.

(2) a8 each January 1 and each July 1.

(3) fd each January 1 and each April 1, July 1 and October 1.

(4) a8 the first day of each month.

(5) a8 immediate upon meeting the eligibility requirements specified in Subsection 1.03(a).

1.04 COMPENSATION

For purposes of determining Contributions under the Plan, Compensation shall be as defined (check (a) or (b) below, as appropriate):
(a) fd in Section 2.01(a)(8), (check (1) or (2) below, if and as appropriate)):
(1) fd but excluding (check the appropriate box(es)):

(A) a8 Overtime Pay.

(B) a8 Bonuses.

(C) a8 Commissions.

(D) fd The value of a qualified or a non-qualified stock option granted to an Employee by the Employer to the extent such value is includable in the Employee92s taxable income.

(E) a8 The following:






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(2) a8 except as otherwise provided below:

(b) a8 in the Plan maintained by the Employer to the extent it is in excess of the limit imposed under Code Section 401(a)(17).

1.05 CONTRIBUTIONS

(a) Employee contributions (Complete all that apply)
(1) fd Deferral Contributions. The Employer shall make a Deferral Contribution in accordance with, and subject to, Section 4.01 on behalf of each Participant who has an executed salary reduction agreement in effect with the Employer for the calendar year (or portion of the calendar year) in question, not to exceed 80 % of Compensation, exclusive of any Bonus.

(2) fd Bonus Contributions. The Employer requires Participants to enter into a special salary reduction agreement to make Deferral Contributions of any percentage of Employer paid cash Bonuses, up to 100% of such Bonuses. (The Compensation definition elected by the Employer in Section 1.04 must include Bonuses if Bonus contributions are permitted.)

(b) a8 Matching Contributions (Choose (1) or (2) below, and (3) below, as applicable.)

(1) a8 The Employer shall make a Matching Contribution on behalf of each Participant in an amount equal to the following percentage of a Participant92s Deferral Contributions during the Plan Year (check one):

(A) a8 50%
(B) a8 100%
(C) a8 %
(D) a8 (Tiered Match) % of the first % of the Participant92s Compensation contributed to the Plan.

(E) o The percentage declared for the year, if any, by a Board of Directors92 resolution.
(F) o Other:

(2) a8 Matching Contribution Offset. For each Participant who has made 401(k) Deferrals at least equal to the maximum under Code Section 402(g) or, if less, the maximum permitted under the Qualified Plan, the Employer shall make a Matching Contribution for the calendar year equal to (A) minus (B) below:

(A) The 401(m) Match that the Participant would have received under the Qualified Plan for such calendar year on the sum of the Participant92s Deferral Contributions and the Participant92s 401(k) Deferrals if no limits otherwise imposed by tax law applied to 401(m) Match and deeming the Participant92s Deferral Contributions to be 401(k) Deferrals.

(B) The 401(m) Match actually allocated to such Participant under the Qualified Plan for the calendar year.





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For purposes of this Section 1.05(b): "Qualified Plan" means the Plan; "401(k) Deferrals" means contributions under the Qualified Plan92s cash or deferred arrangement as defined in Code Section 401(k); and "401(m) Match" means a matching contribution as defined in Code Section 401(m).

(3) a8 Matching Contribution Limits (check the appropriate box(es)):

(A) a8 Deferral Contributions in excess of % of the Participant92s Compensation for the period in question shall not be considered for Matching Contributions.

Note: If the Employer elects a percentage limit in (A) above and requests the Trustee to account separately for matched and unmatched Deferral Contributions, the Matching Contributions allocated to each Participant must be computed, and the percentage limit applied, based upon each period.

(B) a8 Matching Contributions for each Participant for each Plan Year shall be limited to $.

(4) Eligibility Requirement(s) for Matching Contributions . A Participant who makes Deferral Contributions during the Plan Year under Section 1.05(a) shall be entitled to Matching Contributions for that Plan Year if the Participant satisfies the following requirement(s) (Check the appropriate box(es). Options (B) and (C) may not be elected together):

(A) a8 Is employed by the Employer on the last day of the Plan Year.

(B) a8 Earns at least 500 Hours of Service during the Plan Year.

(C) a8 Earns at least 1,000 Hours of Service during the Plan Year.

(D) o Other:

(E) a8 No requirements.

Note: If option (A), (B) or (C) above is selected, then Matching Contributions can only be made by the Employer after the Plan Year ends. Any Matching Contribution made before Plan Year end shall not be subject to the eligibility requirements of this Section 1.05(b)(3)).

(c) Employer Contributions
(1) o Fixed Employer Contributions . The Employer shall make an Employer Contribution on behalf of each Participant in an amount determined as described below (check at least one):





(A) a8 In an amount equal to % of each Participant92s Compensation each Plan Year.

(B) o In an amount determined and allocated as described below:





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(C) a8 In an amount equal to (check at least one):

(i.) a8 Any profit sharing contribution that the Employer would have made on behalf of the Participant under the following qualified defined contribution plan but for the limitations imposed by Code Section 401(a)(17):


(ii.) a8 Any contribution described in Code Section 401(m) that the Employer would have made on behalf of the Participant under the following qualified defined contribution plan but for the limitations imposed by Code Section 401(a)(17):


(2) fd Discretionary Employer Contributions . The Employer may make Employer Contributions to the accounts of Participants in any amount, as determined by the Employer in its sole discretion from time to time, which amount may be zero.

(3) Eligibility Requirement(s) for Employer Contributions . A Participant shall only be entitled to Employer Contributions under Section 1.05(c)(1) for a Plan Year if the Participant satisfies the following requirement(s) (Check the appropriate box(es). Options (B) and (C) may not be elected together):

(A) o Is employed by the Employer on the last day of the Plan Year.

(B) a8 Earns at least 500 Hours of Service during the Plan Year.

(C) a8 Earns at least 1,000 Hours of Service during the Plan Year.

(D) fd Other: Is a Non-Employee Director

(E) o No requirements.

1.06 DISTRIBUTION DATES

Distribution from a Participant92s Account pursuant to Section 8.02 shall begin upon the following date(s) (check either (a) or (b); check (c), if desired):

(a) a8 Non-Class Year Accounting (complete (1) and (2)).

(1) The earliest of termination of employment with the Employer (see Plan Section 7.03) and the following event(s) (check appropriate box(es); if none selected, all distributions will be upon termination of employment):
(A) a8 Attainment of Normal Retirement Age (as defined in Section 1.07(f)).

(B) a8 Attainment of Early Retirement Age (as defined in Section 1.07(g)).





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(C) a8 The date on which the Participant becomes disabled (as defined in Section 1.07(h)).

(2) Timing of distribution (check either (A) or (B)).

(A) o The distribution of the Participant92s Account will be begin in the month following the event described in (a)(1) above, however, if the event is termination of employment, then such distribution will begin as soon as practicable on or after the 1st day of the seventh calendar month following such separation if the Participant was a Key Employee.

(B) a8 The distribution of the Participant92s Account will begin as soon as administratively feasible in the calendar year following distribution event described in (a)(1) above, provided however, that if the event is termination of employment, in no event will such distribution begin earlier than the 1st day of the seventh calendar month following such separation if the Participant was a Key Employee.

(b) fd Class Year Accounting (complete (1) and (2)).

(1) Upon (check at least one; (A) must be selected if plan has contributions pursuant to section 1.05(b) or (c)):

(A) fd Termination of employment with the Employer (see Plan Section 7.03); provided however, that if the event is termination of employment, in no event will such distribution begin earlier than the 1st day of the seventh calendar month following such separation if the Participant was a Key Employee.

(B) fd The date elected by the Participant, pursuant to Plan Section 8.02, and subject to the restrictions imposed in Plan Section 8.02 with respect to future Deferral Contributions, in which event such date of distribution must be at least one year after the date such Deferral Contribution would have been paid to the Participant in cash in the absence of the election to make the Deferral Contribution.

(2) Timing of distribution subject to Subsection (b)(1)(A) above (check either (A) or (B)).

(A) fd The Distribution of the Participant92s Account will begin 03/01 (specify month and day) following the event described in (b)(1) above.

(B) o The Distribution of the Participant92s Account will begin (specify month and day) of the calendar year following the event described in (b)(1) above.

(c) fd Upon a Change of Control in accordance with Plan Section 7.08.





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Note: Internal Revenue Code Section 280G could impose certain, adverse tax consequences on both Participants and the Employer as a result of the application of this Section 1.06(c). The Employer should consult with its attorney prior to electing to apply Section 1.06(c).

1.07 VESTING SCHEDULE

(a) The Participant92s vested percentage in Matching Contributions elected in Section 1.05(b) shall be based upon the schedule(s) selected below.
(1) fd N/A - No Matching Contributions
(2) o 100% Vesting immediately
(3) o 3 year cliff (see C below)
(4) o 5 year cliff (see D below)
(5) o 6 year graduated (see E below)
(6) o 7 year graduated (see F below)
(7) o G below
(8) o Other (Attachment "B")





Years of
Service for Vesting Schedule
Vesting C D E F G

0 0 % 0 % 0 % 0 %
1 0 % 0 % 0 % 0 %
2 0 % 0 % 20 % 0 %
3 100 % 0 % 40 % 20 %
4 100 % 0 % 60 % 40 %
5 100 % 100 % 80 % 60 %
6 100 % 100 % 100 % 80 %
7 100 % 100 % 100 % 100 % 100 %




(b) The Participant92s vested percentage in Employer Contributions elected in Section 1.05(c) shall be based upon the schedule(s) selected below.

(1) o N/A - No Employer Contributions
(2) fd 100% Vesting immediately
(3) o 3 year cliff (see C below)
(4) o 5 year cliff (see D below)
(5) o 6 year graduated (see E below)
(6) o 7 year graduated (see F below)
(7) o G below
(8) o Other (Attachment "B")




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Years of
Service for Vesting Schedule
Vesting C D E F G

0 0 % 0 % 0 % 0 %
1 0 % 0 % 0 % 0 %
2 0 % 0 % 20 % 0 %
3 100 % 0 % 40 % 20 %
4 100 % 0 % 60 % 40 %
5 100 % 100 % 80 % 60 %
6 100 % 100 % 100 % 80 %
7 100 % 100 % 100 % 100 % 100 %




(c) a8 Years of Service for Vesting shall exclude (check one):

(1) a8 for new plans, service prior to the Effective Date as defined in Section 1.01(d)(1).

(2) o for existing plans converting from another plan document, service prior to the original Effective Date as defined in Section 1.01(d)(2).

(d) a8 A Participant will forfeit his Matching Contributions and Employer Contributions upon the occurrence of the following event (s):


(e) A Participant will be 100% vested in his Matching Contributions and Employer Contributions upon (check the appropriate box(es), if any; if 1.06(c) is selected, Participants will automatically vest upon Change of Control as defined in Section 1.12):

(1) a8 Normal Retirement Age (as defined in Section 1.07(f)).

(2) a8 Early Retirement Age (as defined in Section 1.07(g)).

(3) a8 Death.

(4) a8 The date on which the Participant becomes disabled, as determined under Section 1.07(h) of the Plan.

(f) Normal Retirement Age under the Plan is (check one):

(1) fd age 65.

(2) o age (specify from 55 through 64).

(3) o the later of age (cannot exceed 65) or the fifth anniversary of the Participant92s Commencement Date.

If no box is checked in this Section 1.07(f), then Normal Retirement Age is 65.




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(g) a8 Early Retirement Age is the first day of the month after the Participant attains age (specify 55 or greater) and completes Years of Service for Vesting.

(h) fd A Participant is considered disabled when that Participant (check one):

(1) fd is unable to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or can be expected to last for a continuous period of not less than 12 months.

(2) o is, by reason of any medically determinable physical or mental impairment which can be expected to result in death or can be expected to last for a continuous period of not less than 12 months, receiving income replacement benefits for a period of not less than 3 months under an accident and health plan covering employees of the Employer.

1.08 PREDECESSOR EMPLOYER SERVICE

a8 Service for purposes of vesting in Section 1.07(a) and (b) shall include service with the following employer(s):

1.09 UNFORESEEABLE EMERGENCY WITHDRAWALS

Participant withdrawals for unforeseeable emergency prior to termination of employment (check one):
(a) fd will be allowed in accordance with Section 7.07, subject to a $ 1,000 minimum amount. (Must be at least $1,000)

(b) a8 will not be allowed.

1.10 DISTRIBUTIONS

Subject to Articles 7 and 8 distributions under the Plan are always available as a lump sum. Check below to allow distributions in installment payments :

fd under a systematic withdrawal plan (installments) not to exceed 10 years which (check one if box for this Section is selected):

(a) a8 will not be accelerated, regardless of the Participant92s Account balance.

(b) fd will be accelerated to a lump sum distribution in accordance with Section 8.03.

1.11 INVESTMENT DECISIONS

(a) Investment Directions
Investments in which the Accounts of Participants shall be treated as invested and reinvested shall be directed (check one):

(1) a8 by the Employer among the options listed in (b) below.




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(2) a8 by each Participant among the options listed in (b) below.

(3) fd in accordance with investment directions provided by each Participant for all contribution sources in a Participant92s Account except the following sources shall be invested as directed by the Employer (check (A) and/or (B)):

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