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Supplemental Indenture Dated June 8, 2010 Senior Subordinated Notes Due 2014

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SUPPLEMENTAL INDENTURE (this " Supplemental Indenture" ), dated as of June 8, 2010, among Angiotech America, Inc. and Angiotech Florida Holdings, Inc. (each, a " Guaranteeing Subsidiary" and, collectively, the " Guaranteeing Subsidiaries" ), subsidiaries of Angiotech Pharmaceuticals, Inc. (or its permitted successor), a corporation organized under the Business Corporations Act of the Province of British Columbia (the " Company" ), the Company, the other Guarantors (as defined in the Indenture referred to herein) and Deutsche Bank National Trust Company, as successor to Wells Fargo Bank, N.A., as trustee under the Indenture referred to below (the " Trustee" ).


WHEREAS, the Company has heretofore executed and delivered to the Trustee an indenture (the " Indenture" ), dated as of March 23, 2006, providing for the issuance of 7.75% Senior Subordinated Notes due 2014 (the " Notes" );

WHEREAS, the Indenture provides that under certain circumstances the Guaranteeing Subsidiaries shall execute and deliver to the Trustee a supplemental indenture pursuant to which the Guaranteeing Subsidiaries shall unconditionally guarantee all of the Company' s Obligations under the Notes and the Indenture on the terms and conditions set forth herein (the " Note Guarantee" ); and

WHEREAS, pursuant to Section 9.01 of the Indenture, the Trustee is authorized to execute and deliver this Supplemental Indenture.

NOW, THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt of which is hereby acknowledged, the Guaranteeing Subsidiaries and the Trustee mutually covenant and agree for the equal and ratable benefit of the Holders of the Notes as follows:

1. CAPITALIZED TERMS. Capitalized terms used herein without definition shall have the meanings assigned to them in the Indenture.

2. AGREEMENT TO GUARANTEE. The Guaranteeing Subsidiaries hereby agree to provide an unconditional Guarantee on the terms and subject to the conditions set forth in the Note Guarantee and in the Indenture including but not limited to Article 11 thereof.

3. NO RECOURSE AGAINST OTHERS. No past, present or future director, officer, employee, incorporator, stockholder or agent of the Guaranteeing Subsidiaries, as such, shall have any liability for any obligations of the Company or any of the Guaranteeing Subsidiaries under the Notes, any Note Guarantees, the Indenture or this Supplemental Inde
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