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Vice President of Sales Severance Agreement

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ANIKA THERAPEUTICS, INC.
CHANGE IN CONTROL, BONUS AND SEVERANCE AGREEMENT


AGREEMENT made as of April 26, 2000 by and among Anika Therapeutics, Inc., a Massachusetts corporation with its principal place of business in Woburn, Massachusetts (the "Company"), and Edward Ross, Jr., of Lexington, Massachusetts (the "Executive"), an individual presently employed as the Vice President of Sales and Marketing of the Company.


1. PURPOSE. The Company considers it essential to the best interests of its stockholders to foster the continuous employment of key management personnel. The Board of Directors of the Company (the "Board") recognizes, however, that, as is the case with many publicly held corporations, the possibility of a Change in Control (as defined in Section 2 hereof) exists and that such possibility, and the uncertainty and questions which it may raise among management, may result in the departure or distraction of management personnel to the detriment of the Company and its stockholders. Therefore, the Board has determined that appropriate steps should be taken to reinforce and encourage the continued attention and dedication of members of the Company's management, including the Executive, to their assigned duties without distraction in the face of potentially disturbing circumstances arising from the possibility of a Change in Control. Nothing in this Agreement shall be construed as creating an express or implied contract of employment and, except as otherwise agreed in writing between the Executive and the Company, the Executive shall not have any right to be retained in the employ of the Company.


2. CHANGE IN CONTROL. A "Change in Control" shall mean the occurrence of any one of the following events:


(a) any "person," as such term is used in Sections 13(d) and 14(d) of
the Securities Exchange Act of 1934 (the "Act") (other than the Company, any
of its subsidiaries, any trustee, fiduciary or other person or entity
holding securities under any employee benefit plan or trust of the Company
or any of its subsidiaries), together with all "affiliates" and "associates"
(as such terms are defined in Rule 12b-2 under the Act) of such person,
shall become the "beneficial owner" (as such term is defined in Rule 13d-3
under the Act), directly or indirectly, of securities of the Company
representing 51% or more of the combined voting power of the Company's then
outstanding securities having the right to vote in an election of the
Company's Board of Directors ("Voting Securities"); or


(b) persons who, as of the date hereof, constitute the Company's Board
of Directors (the "Incumbent Directors") cease for any reason, including,
without limitation, as a result of a tender offer, proxy contest, merger or
similar transaction, to


constitute at least a majority of the Board, provided that any person
becoming a director of the Company subsequent to the date hereof whose
election or nomination for election was approved by a vote of at least a
majority of the Incumbent Directors shall, for purposes of this
Agreement, be considered an Incumbent Director; or


(c) the stockholders of the Company shall approve (A) any consolidation
or merger of the Company where the shareholders of the Company, immediately
prior to the consolidation or merger, would not, immediately after the
consolidation or merger, beneficially own (as such term is defined in
Rule 13d-3 under the Act), directly or indirectly, shares representing in
the aggregate 51% of the voting shares of the corporation issuing cash or
securities in the consolidation or merger (or of its ultimate parent
corporation, if any), (B) any sale, lease, exchange or other transfer (in
one transaction or a series of transactions contemplated or arranged by any
party as a single plan) of all or substantially all of the assets of the
Company or (C) any plan or proposal for the liquidation or dissolution of
the Company.


Notwithstanding the foregoing, a "Change in Control" shall not be deemed to have occurred for purposes of the foregoing clause (a) solely as the result of an acquisition of securities by the Company which, by reducing the number of shares of Voting Securities outstanding, increases the proportionate voting power represented by the Voting Securities beneficially owned by any person to 51% or more of the combined voting power of all then outstanding Voting Securities; provided, however, that if any person referred to in this sentence shall thereafter become the beneficial owner of any additional shares of Voting Securities (other than pursuant to a share split, stock dividend or similar transaction or direct purchase from the Company), then a "Change in Control" shall be deemed to have occurred for purposes of the foregoing clause (a).


3. TERMINATING EVENT. A "Terminating Event" shall mean any of the events provided in this Section 3 occurring within twelve (12) months subsequent to a Change in Control as defined in Section 2:


(a) termination by the Company of the employment of the Executive with
the Company for any reason other than for Cause or the death of the
Executive. "Cause" shall mean, and shall be limited to, the occurrence of
any one or more of the following events:


(i) a willful act of dishonesty by the Executive with respect to any
matter involving the Company;


(ii) conviction of the Executive of a crime involving moral
turpitude; or


2


(iii) the deliberate or willful failure by the Executive (other than
by reason of the Executive's physical or mental illness, incapacity or
disability) to substantially perform the Executive's duties with the
Company and the continuation of such failure for a period of 30 days
after delivery by the Company to the Executive of written notice
specifying the scope and nature of such failure and its intention to
terminate the Executive for Cause.


A Terminating Event shall not be deemed to have occurred pursuant to
this Section 3(a) solely as a result of the Executive being an employee of
any direct or indirect successor to the business or assets of the Company,
rather than continuing as an employee of the Company following a Change in
Control.


(b) termination by the Executive of the Executive's employment with the
Company for Good Reason. "Good Reason" shall mean the occurrence of any of
the following events:


(i) a substantial adverse change in the nature or scope of the
Executive's responsibilities or duties from the responsibilities or
duties exercised by the Executive immediately prior to the Change in
Control, it being understood by the parties hereto, that so long as the
Executive retains prima
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