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Consulting Agreement

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Exhibit 10.277

CONSULTING AGREEMENT

This CONSULTING AGREEMENT (the " Agreement" ) is made this 4 th day of February, 2011, to be effective on May 19, 2011, by and between Pharmaceutical Product Development, Inc., a North Carolina corporation with its principal place of business in New Hanover County, North Carolina (the " Company" ), and David L. Grange, a citizen and resident of New Hanover County, North Carolina (" Consultant" ). (Hereinafter, the Company and Consultant are sometimes referred to each as a " Party" and together as the " Parties ." )

WHEREAS, Consultant has been employed by the Company as its Chief Executive Officer; and

WHEREAS, Consultant has elected to retire from the Company, effective as of May 18, 2011, and has entered into that certain Separation and Release Agreement of even date herewith with the Company (the " Separation Agreement" );

WHEREAS, for a period of time following the termination of his employment with the Company, Consultant has agreed to provide certain consulting services to the Company subject to the conditions of this Agreement; and

NOW, THEREFORE, in consideration of the mutual promises and agreements set forth herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby expressly acknowledged, the Parties hereby agree as follows.

1. Services . The services to be performed by Consultant under this Agreement are set forth on Exhibit A , attached hereto, and are hereafter referred to as the " Services ." Consultant will not be expected to devote more than twenty (20) hours per week during normal business hours, Monday through Friday, in performing the Services. Consultant agrees to perform the Services in a timely and professional manner and at the direction of the Company' s Board of Directors or Executive Chairman.

2. Consulting Term . The term of this Agreement will commence as of May 19, 2011 and shall continue through December 31, 2011, unless earlier terminated pursuant to Section 4 (the " Consulting Term" ).

3. Compensation . During the Consulting Term, the Company will pay Consultant a monthly consulting fee in the amount of $50,000.00 per month (the " Monthly Consulting Fee" ). During the Consulting Term, the Company will pay Consultant the Monthly Consulting Fee on or before the tenth (10 th ) day of the month following the month in which Consultant was obligated to provide the Services. For any month during the Consulting Term that is less than a full calendar month, the Monthly Consulting Fee will be prorated based on the number of days in such month for which this Agreement was in effect as compared to the total number of days in such month. The Company further agrees to reimburse Consultant for all reasonable business expenses incurred by Consultant in connection with providing the Services, provided that the Company has approved such business expenses in advance.

4. Termination .

a. Termination for Cause . At any time prior to the end of the Consulting Term, the Company may terminate this Agreement immediately and without advanced notice for " Cause." For purposes of this Agreement, " Cause" shall mean and include: (i) Consultant' s material breach of this Agreement or any other agreement between Consultant and the Company; (ii) Consultant' s commission of a felony or crime involving moral turpitude; (iii) any act by Consultant involving dishonesty in the performance of the Services, including, without limitation, fraud, misappropriation or embezzlement; (iv) Consultant' s repeated failure or refusal to perform the Services; (v) any willful or grossly negligent act or omission by Consultant that is injurious to the Company, including injury to the Company' s reputation; or (vi) Consultant' s revocation of the Separation Agreement. If the Company terminates this Agreement for Cause, the Company will pay Consultant only that portion of the Monthly Consulting Fee due to Consultant for Services performed through the effective date of the termination and any pre-approved business expenses in accordance with Section 3, above.

b. Other Termination . This Agreement shall terminate immediately upon Consultant' s death or " Disability." For purposes of this Agreement, " Disability" is defined as Consultant' s inability to perform the Services for a period of thirty (30) consecutive days. If this Agreement is terminated due to Consultant' s death or Disability, the Company will pay Consultant only that portion of the Monthly Consulting Fee due to Consultant for Services performed through the effective date of the termination and any pre-approved business expenses in accordance with Section 3, above.

5. Independent Contractor Status .
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